Nuclear Magnetic Resonance (NMR)

Summary

The WCM CLC Nuclear Magnetic Resonance (NMR) Core Facility provides state-of-the-art biological and chemical nuclear magnetic resonance resources and services, and expertise in their analytical, structural and biochemical applications, to the Weill Cornell Medicine (WCM) community and to outside investigators.  Services include sample preparation, NMR data collection and data analysis.  The core facility provides consultation on project design and data analysis, and offers seminars, training and educational workshops.

Overview

Background: NMR is an essential component of structural biology since it is uniquely suited to examine changes in the conformation, structure and mobility of biomolecules using solution conditions closely approximating the biological environment.  NMR is critical for chemical analysis and synthetic chemistry, is essential for characterizing and verifying chemical compounds.  Basic NMR applications can be employed for assessing sample purity, chemical changes, binding events and the effects of mutations. More involved multidimensional NMR applications can be implemented for protein structure determination and dynamics investigations.        

History: The NMR Core Facility was founded in 1999 to support structural biology, biochemistry, analytical and medicinal chemistry.The core became part of the WCM Core Laboratories Center (CLC) in 2015. Since this time the NMR Core has expanded four instruments with purchases made possible through NIH S10 instrumentation awards and institutional support.     

Location: The NMR Core Facility has NMR instruments sited at two locations: Citigroup Biomedical Imaging center, 516 East 72nd Street S152, New York, NY, and within the Belfer Research Building at 413 East 69th Street BB000.53, New York, NY. 

WCM Core Laboratories Center (CLC): The WCM CLC was established in 2015.  The CLC includes core facilities that offer resources and services in genomics and epigenomics, proteomics and metabolomics, flow cytometry, imaging (e.g., optical and electron microscopy, high content screening, MRI, PET/CT, and ultrasound), synthetic and analytical chemistry, and nuclear magnetic resonance (NMR).

Open to all: The resources and services of the core facility are open to all investigators at Weill Cornell Medicine, Cornell University and Cornell-affiliated institutions.  The facility also provides services to external investigators at both academic institutions and commercial enterprises.